Anti-inflammatory activity of plant sterols in a co-culture model of intestinal inflammation: focus on food-matrix effect
Nerea Faubel, Mussa Makran, Reyes Barberá, Guadalupe García‐Llatas, Ilenia Concetta Giardina, Luisa Tesoriere, Alessandro Attanzio, Antonio Cilla
Abstract
production (27%). Co-treatment with budesonide and PS-FS displayed an antagonistic effect (combination index 0.38-0.63). This study demonstrates the potent intestinal anti-inflammatory activity of a PS-FS, positioning it as a promising nutraceutical product for the management of inflammatory bowel diseases. However, the food matrix of the milk-based fruit beverage and rye bread appear to interfere with the anti-inflammatory activity of PS.
Topics & Concepts
Plant sterolsFood scienceMatrix (chemical analysis)ChemistryInflammationFunctional foodSterolBiologyBiochemistryCholesterolImmunologyChromatographyCholesterol and Lipid MetabolismInflammatory Bowel DiseaseMoringa oleifera research and applications