Design, synthesis, and evaluation of potent RIPK1 inhibitors with in vivo anti-inflammatory activity
Zhanhui Li, Yongjin Hao, Chengkui Yang, Qing Yang, S. C. Wu, Haikuo Ma, Sheng Tian, Haohao Lu, Jingrui Wang, Tao Yang, Sudan He, Xiaohu Zhang
Topics & Concepts
NecroptosisRIPK1ChemistryIn vivoPharmacologyProgrammed cell deathIn vitroBiochemistryApoptosisBiologyBiotechnologyCell death mechanisms and regulationinterferon and immune responsesNF-κB Signaling Pathways