Pseudouridine synthase 1 regulates erythropoiesis via transfer RNAs pseudouridylation and cytoplasmic translation
Deyang Shi, Bichen Wang, Haoyuan Li, Yu Lian, Qiuyi Ma, Tong Liu, Mutian Cao, Yuanwu Ma, Shi Lei, Weiping Yuan, Jun Shi, Yajing Chu
Abstract
We demonstrated the critical role of pseudouridylation in regulating tRNA homeostasis, cytoplasmic translation, and erythropoiesis.
Topics & Concepts
PseudouridineErythropoiesisSmall nucleolar RNABiologyTranslation (biology)Cell biologySideroblastic anemiaTransfer RNAMolecular biologyBiochemistryChemistryRNALong non-coding RNAAnemiaGeneMessenger RNAInternal medicineMedicineRNA modifications and cancerBiochemical and Molecular ResearchMetabolism and Genetic Disorders