Design, synthesis and molecular docking of new [1,2,4] triazolo[4,3-a]quinoxaline derivatives as anticancer agents targeting VEGFR-2 kinase
Nawaf A. Alsaif, Alaa Elwan, Mohammed M. Alanazi, Ahmad J. Obaidullah, Wael A. Alanazi, Abdullah F. Alasmari, Hussam Albassam, Hazem A. Mahdy, Mohammed S. Taghour
Topics & Concepts
SorafenibCytotoxicityQuinoxalineIC50Docking (animal)ChemistryStereochemistryCytotoxic T cellIn vitroKinaseKinase insert domain receptorBiochemistryPharmacologyVEGF receptorsBiologyVascular endothelial growth factorCancer researchVascular endothelial growth factor AOrganic chemistryMedicineNursingHepatocellular carcinomaSynthesis and Biological EvaluationQuinazolinone synthesis and applicationsSynthesis and biological activity