Ni-Catalyzed Electro-Reductive Cross-Electrophile Couplings of Alkyl Amine-Derived Radical Precursors with Aryl Iodides
Lars J. Wesenberg, Alessandra Sivo, Gianvito Vilé, Timothy Noël
Abstract
High Resolution Image Download MS PowerPoint Slide In recent years, the “Escape-from-Flatland” trend has prompted the synthetic community to develop a set of cross-coupling strategies to introduce sp 3 -carbon-based fragments in organic compounds. This study presents a novel nickel-catalyzed electrochemical methodology for reductive cross-electrophile coupling. The method enables C(sp 2 )–C(sp 3 ) linkages using inexpensive amine-derived radical precursors and aryl iodides. The use of electrochemistry as a power source reduces waste and avoids chemical reductants, making this approach a more sustainable alternative to traditional cross-coupling methods.
Topics & Concepts
ElectrophileArylAmine gas treatingAlkylElectrochemistryCatalysisCombinatorial chemistryChemistryCoupling reactionCoupling (piping)NickelReductive eliminationOrganic chemistryMaterials scienceElectrodePhysical chemistryMetallurgyRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques