[The way to reduce the false negative results of 2019 novel coronavirus nucleic acid detection].
R Zhang, J M Li
Abstract
核酸检测是新型冠状病毒肺炎(novel coronavirus pneumonia, NCP)确诊的重要手段，但是目前临床上反映存在较高比例核酸检测"假阴性"的问题。本文将明确核酸检测"假阴性"的概念，核酸检测为什么可以作为感染确诊"假阴性"，并分析造成核酸检测"假阴性"的原因。在核酸检测基础上，补充SARS-CoV-2病毒特异性IgM/IgG抗体的联合动态多次检测，可以明显减少有病毒性肺炎临床症状和影像学证据、但核酸多次或始终检测为阴性的临床层面上的"假阴性"，对临床诊断病例的最终确诊和准确性评价具有重要意义。.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)CoronavirusNucleic acid2019-20 coronavirus outbreakVirologyPneumoniaNucleic acid detectionFalse Negative ReactionsCoronavirus InfectionsSevere acute respiratory syndrome coronavirusBiologyMedicineGeneticsOutbreakPathologyInternal medicineInfectious disease (medical specialty)DiseaseSARS-CoV-2 detection and testingSARS-CoV-2 and COVID-19 ResearchImmune responses and vaccinations