Neutrophil extracellular traps enhance macrophage killing of bacterial pathogens
Andrew J. Monteith, Jeanette M. Miller, C. Noel Maxwell, Walter Chazin, Eric P. Skaar
Abstract
, implicating this as an immune defense mechanism that broadly enhances antibacterial activity. These results demonstrate that achieving maximal bactericidal activity through NET formation requires macrophages and that accelerated and more robust suicidal NETosis makes neutrophils adept at increasing antibacterial activity, especially when A9 deficient.
Topics & Concepts
Neutrophil extracellular trapsInnate immune systemPhagocytosisMicrobiologyStaphylococcus aureusImmune systemExtracellularBiologyStreptococcus pneumoniaeMacrophageAntimicrobial peptidesPseudomonas aeruginosaImmunologyBacteriaAntimicrobialInflammationCell biologyAntibioticsIn vitroBiochemistryGeneticsNeutrophil, Myeloperoxidase and Oxidative MechanismsS100 Proteins and AnnexinsAdvanced Nanomaterials in Catalysis