Inhibitor Mimetic Mutations in the <i>Pseudomonas aeruginosa</i> PqsE Enzyme Reveal a Protein–Protein Interaction with the Quorum-Sensing Receptor RhlR That Is Vital for Virulence Factor Production
Isabelle R. Taylor, Jon E. Paczkowski, Philip D. Jeffrey, Brad R. Henke, Chari D. Smith, Bonnie L. Bassler
Abstract
. These findings provide a new route for drug discovery efforts targeting PqsE.
Topics & Concepts
Quorum sensingPseudomonas aeruginosaVirulenceVirulence factorBiologyMicrobiologyEnzymePathogenPlasma protein bindingBiofilmBiochemistryBacteriaGeneGeneticsBacterial biofilms and quorum sensingAntibiotic Resistance in BacteriaBacterial Genetics and Biotechnology