Prevalence and Clinical Implications of Epstein-Barr Virus Infection in De Novo Diffuse Large B-Cell Lymphoma in Western Countries
Weiyun Z. Ai, Eric D. Hsi, Ken H. Young, Andrés J.M. Ferreri, Carlo Visco, Ling Li, Karen Dybaer, Miguel Á. Piris, Govind Bhagat, Jooryung Huh, J. Han van Krieken, Kristy L. Richards, Jiayu Chen, Maurilio Ponzoni, Jane N. Winter, L. Jeffrey Medeiros, Tzankov, Alexander, Carlo E. Bueso-Ramos, Ganiraju C. Manyam, Youli Zu, Santiago Montes‐Moreno, William W.L. Choi, April Chiu, Roberto N. Miranda, Michael Møller, Attilio Orazi, Chi Young Ok, Zijun Y. Xu‐Monette, John P. Farnen
Abstract
Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) of the elderly is a variant of DLBCL with worse outcome that occurs most often in East Asian countries and is uncommon in the Western hemisphere. We studied the largest cohort of EBV+ DLBCL, independent of age, treated with R-CHOP in developed Western countries.