Towards a unified open access dataset of molecular interactions
Pablo Porras, Elisabet Barrera, Alan Bridge, Noemí del‐Toro, Gianni Cesareni, Margaret Duesbury, Henning Hermjakob, Marta Iannuccelli, Igor Jurišica, Max Kotlyar, Luana Licata, Ruth C. Lovering, David J. Lynn, Birgit Meldal, Bindu Nanduri, Kalpana Paneerselvam, Simona Panni, Chiara Pastrello, Matteo Pellegrini, Livia Perfetto, Negin Rahimzadeh, Prashansa Ratan, Sylvie Ricard‐Blum, Łukasz Salwiński, Gautam Shirodkar, Anjali Shrivastava, Sandra Orchard
Abstract
The International Molecular Exchange (IMEx) Consortium provides scientists with a single body of experimentally verified protein interactions curated in rich contextual detail to an internationally agreed standard. In this update to the work of the IMEx Consortium, we discuss how this initiative has been working in practice, how it has ensured database sustainability, and how it is meeting emerging annotation challenges through the introduction of new interactor types and data formats. Additionally, we provide examples of how IMEx data are being used by biomedical researchers and integrated in other bioinformatic tools and resources.