Proteomic discovery of chemical probes that perturb protein complexes in human cells
Michael R. Lazear, Jarrett R. Remsberg, Martin G. Jaeger, Katherine Rothamel, Hsuan-Lin Her, Kristen E. DeMeester, Evert Njomen, Simon J. Hogg, Jahan Rahman, Landon R. Whitby, Sang Joon Won, Michael A. Schafroth, Daisuke Ogasawara, Minoru Yokoyama, Garrett L. Lindsey, Haoxin Li, Jason Germain, Sabrina Barbas, Joan Vaughan, Thomas W. Hanigan, Vincent F. Vartabedian, Christopher J. Reinhardt, Melissa M. Dix, Seong Joo Koo, Inha Heo, John R. Teijaro, Gabriel M. Simon, B.K. Ghosh, Omar Abdel‐Wahab, Kay Ahn, Alan Saghatelian, Bruno Melillo, Stuart L. Schreiber, G Yeo, Benjamin F. Cravatt
Topics & Concepts
BiologySpliceosomeProteomicsCysteineProtein functionComputational biologyFunction (biology)Chemical biologyDrug discoverySmall moleculeBiochemistryPlasma protein bindingProtein–protein interactionChemical geneticsCell biologyGeneEnzymeRNA splicingRNAUbiquitin and proteasome pathwaysClick Chemistry and ApplicationsProtein Degradation and Inhibitors