Litcius/Paper detail

Proteomic discovery of chemical probes that perturb protein complexes in human cells

Michael R. Lazear, Jarrett R. Remsberg, Martin G. Jaeger, Katherine Rothamel, Hsuan-Lin Her, Kristen E. DeMeester, Evert Njomen, Simon J. Hogg, Jahan Rahman, Landon R. Whitby, Sang Joon Won, Michael A. Schafroth, Daisuke Ogasawara, Minoru Yokoyama, Garrett L. Lindsey, Haoxin Li, Jason Germain, Sabrina Barbas, Joan Vaughan, Thomas W. Hanigan, Vincent F. Vartabedian, Christopher J. Reinhardt, Melissa M. Dix, Seong Joo Koo, Inha Heo, John R. Teijaro, Gabriel M. Simon, B.K. Ghosh, Omar Abdel‐Wahab, Kay Ahn, Alan Saghatelian, Bruno Melillo, Stuart L. Schreiber, G Yeo, Benjamin F. Cravatt

2023Molecular Cell94 citationsDOIOpen Access PDF

Topics & Concepts

BiologySpliceosomeProteomicsCysteineProtein functionComputational biologyFunction (biology)Chemical biologyDrug discoverySmall moleculeBiochemistryPlasma protein bindingProtein–protein interactionChemical geneticsCell biologyGeneEnzymeRNA splicingRNAUbiquitin and proteasome pathwaysClick Chemistry and ApplicationsProtein Degradation and Inhibitors