Carnosic acid protects against doxorubicin-induced cardiotoxicity through enhancing the Nrf2/HO-1 pathway
Shan Hu, Beilei Liu, Manqi Yang, Shuai Mao, Hao Ju, Zheyu Liu, Min Huang, Gang Wu
Abstract
activating the Nrf2-related cytoprotective system and protected the heart from oxidative damage, apoptosis, and pyroptosis, implying that the use of CA could be a potential therapeutic strategy in the prevention of DOX-associated myocardiopathy.
Topics & Concepts
CardiotoxicityPharmacologyOxidative stressDoxorubicinChemistryPyroptosisApoptosisReactive oxygen speciesMedicineToxicityBiochemistryProgrammed cell deathInternal medicineChemotherapyOrganic chemistryChemotherapy-induced cardiotoxicity and mitigationElectron Spin Resonance StudiesHeme Oxygenase-1 and Carbon Monoxide