Hibifolin, a Natural Sortase A Inhibitor, Attenuates the Pathogenicity of Staphylococcus aureus and Enhances the Antibacterial Activity of Cefotaxime
Song Wu, Li Wang, Yinghua Zhao, Yinghua Zhao, G. Lanzi, Xingye Wang, Chi Zhang, Jiyu Guan, Wei Wang, Xuerui Guo, Ying Meng, Bingmei Wang, Yicheng Zhao, Yicheng Zhao
Abstract
value of 31.20 μg/mL. Hibifolin attenuated the pathogenic behavior of Staphylococcus aureus, including adhesion, invasion, and biofilm formation. Binding assays showed that hibifolin bound to SrtA protein directly. Hibifolin improved the survival of pneumonia induced by S. aureus USA300 in mice and alleviated the pathological damage. Moreover, hibifolin showed a synergistic antibacterial effect with cefotaxime in USA300-infected mice.
Topics & Concepts
Staphylococcus aureusCefotaximeMicrobiologySortase APathogenicityAntibioticsBiologyBacteriaGeneticsBiochemical and Structural CharacterizationBotanical Research and ChemistryToxin Mechanisms and Immunotoxins