Tumor microenvironment responsive self-cascade catalysis for synergistic chemo/chemodynamic therapy by multifunctional biomimetic nanozymes
Nannan Zheng, Fu Yang, Xijian Liu, Ziwen Zhang, Jinxia Wang, Qixiang Mei, Xingyan Wang, Guoying Deng, Jie Lü, Junqing Hu
Abstract
, enhancing CDT by supplementing a sufficiently reactive material and cutting off the energy supply of the tumor by consuming glucose. Simultaneously, Se enhances the chemotherapy of doxorubicin hydrochloride (DOX) and CDT by upregulating ROS in the tumor cells, achieving remarkable inhibition effect towards tumor. Moreover, SSMA/DOX NCs have good biocompatibility and degradability, which avoid long-term toxicity and side effects. Overall, the degradable SSMA/DOX NCs provide an innovative strategy for tumor microenvironment responsive self-cascade catalysis to enhance tumor therapy.
Topics & Concepts
Tumor microenvironmentCascadeNanotechnologyChemistryMaterials scienceTumor cellsCancer researchBiologyChromatographyNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisNanocluster Synthesis and Applications