Urokinase loaded black phosphorus nanosheets for sequential thrombolysis and reactive oxygen species scavenging in ischemic stroke treatment
Dongya Wang, Qianqian Zhao, Jingcan Qin, Yuanyuan Guo, Chuan Zhang, Yuehua Li
Abstract
studies show that the BPNs can cross the BBB with the assistance of laser irradiation, owing to their good photothermal properties. Further experiments show the effectiveness of BPNs for attenuating reperfusion injury and achieving neuroprotection. These results highlight the promising potential of the present BPN-based nanodrugs for the treatment of ROS-related diseases.
Topics & Concepts
Reactive oxygen speciesUrokinaseThrombolysisThrombusChemistryDissolutionOxygenPhosphorusIschemic strokeIschemiaBiophysicsBiochemistryInternal medicineMedicineBiologyMyocardial infarctionOrganic chemistryPhysical chemistryNanoplatforms for cancer theranosticsExtracellular vesicles in diseaseAdvanced Nanomaterials in Catalysis