Reprogramming Exosomes to Escape from Immune Surveillance for Mitochondrial Protection in Hepatic Ischemia-Reperfusion Injury
Shanshan Liu, Xinyu Xiao, Zhang La, Jianwei Wang, Wei Zhao, Haichuan Liu, Rui Liao, Zhi Li, Mengxia Xu, Jiao Guo, Baoyong Zhou, Chengyou Du, Qiling Peng, Ning Jiang
Abstract
The reprogramming of exosomes with CD47 and HuR for targeted delivery of CsA and miR inhibitors represents a promising therapeutic strategy for addressing HIRI. This approach shows potential for safe and effective clinical applications in the treatment of HIRI.
Topics & Concepts
MicrovesiclesExosomeMitochondrial permeability transition poreMicrovesicleTFAMMitochondrionReperfusion injuryCell biologymicroRNAImmune systemIschemiaCancer researchMedicineBiologyImmunologyApoptosisMitochondrial biogenesisBiochemistryProgrammed cell deathGeneCardiologyExtracellular vesicles in diseaseMicroRNA in disease regulationRNA Interference and Gene Delivery