Identification of 34 genes conferring genetic and pharmacological risk for the comorbidity of schizophrenia and smoking behaviors
Yunlong Ma, Jinɡjinɡ Li, Yi Xu, Yan Wang, Yinghao Yao, Qiang Liu, Maiqiu Wang, Xinyi Zhao, Rongli Fan, Jiali Chen, Bin Zhang, Zhen Cai, Haijun Han, Zhongli Yang, Wenji Yuan, Yigang Zhong, Xiangning Chen, Z Jennie, Thomas J. Payne, Yizhou Xu, Yuping Ning, Wenyan Cui, Ming D. Li
Abstract
data, we demonstrated that the expression profiles of the 34 genes were significantly altered by multiple psychotropic drugs. Together, this multi-omics study not only reveals target genes for new drugs to treat SCZ but also reveals new insights into the shared genetic vulnerabilities of SCZ and smoking behaviors.
Topics & Concepts
ComorbidityIdentification (biology)Schizophrenia (object-oriented programming)GeneGeneticsMedicinePsychiatryComputational biologyBioinformaticsPsychologyBiologyBotanyGenetic Associations and EpidemiologyEpigenetics and DNA MethylationChild and Adolescent Psychosocial and Emotional Development