Anticancer and Anti-Inflammatory Effects of Tomentosin: Cellular and Molecular Mechanisms
Nasreddine El Omari, Naoual El Menyiy, Gökhan Zengin, Bey Hing Goh, Monica Gallo, Domenico Montesano, Daniele Naviglio, Abdelhakim Bouyahya
Abstract
Tomentosin is a natural compound known for its presence in some medicinal plants of the Asteraceae family such as Inula viscosa. Recent studies have highlighted its anticancer and anti-inflammatory properties. Its anticancer mechanisms are unique and act at different levels ranging from cellular organization to molecular transcriptional factors and epigenetic modifications. Tomentosin’s possession of the modulatory effect on telomerase expression on tumor cell lines has captured the interest of researchers and spurred a more robust study on its anticancer effect. Since inflammation has a close link with cancer disease, this natural compound appears to be a potential cancer-fighting drug. Indeed, its recently demonstrated anti-inflammatory action can be considered as a starting point for its evaluation as an anticancer chemo-preventive agent