Febuxostat-based amides and some derived heterocycles targeting xanthine oxidase and COX inhibition. Synthesis, in vitro and in vivo biological evaluation, molecular modeling and in silico ADMET studies
Aya Y. Rashad, Shaymaa E. Kassab, Hoda G. Daabees, Ahmed E. Abdel Moneim, Sherif A. F. Rostom
Topics & Concepts
FebuxostatChemistryXanthine oxidaseIn vivoDocking (animal)PharmacologyIn silicoIC50In vitroStereochemistryBiochemistryEnzymeHyperuricemiaUric acidGeneNursingBiologyBiotechnologyMedicineGout, Hyperuricemia, Uric AcidBiochemical and Molecular ResearchChemical synthesis and pharmacological studies