Non-Stabilized Vinyl Anion Equivalents from Styrenes by N-Heterocyclic Carbene Catalysis and Its Use in Catalytic Nucleophilic Aromatic Substitution
Sora Ito, Hayato Fujimoto, Mamoru Tobisu
Abstract
A protocol for the catalytic nucleophilic activation of unactivated styrenes is reported, which enables the generation of a non-stabilized alkenyl anion equivalent as a transient intermediate. In the reaction, N-heterocyclic carbenes add across styrenes to generate ylide intermediates, which can then be used in intramolecular nucleophilic aromatic substitution reactions of aryl fluorides, chlorides, and methyl ethers. The method allows for straightforward access to complex polyaromatic compounds.
Topics & Concepts
ChemistryCarbeneCatalysisIntramolecular forceNucleophilic aromatic substitutionNucleophileNucleophilic substitutionArylYlideMedicinal chemistryOrganic chemistryAlkylN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic Cross-Coupling ReactionsFluorine in Organic Chemistry