Glucocerebrosidase as a therapeutic target for Parkinson’s disease
Yu Chen, Richard Sam, Pankaj Sharma, Lu Chen, Jenny Do, Ellen Sidransky
Abstract
-associated parkinsonism is essential, enhancing levels of brain glucocerebrosidase may have wide therapeutic implications. While gene therapy may ultimately be effective, less expensive and invasive small-molecule non-inhibitory chaperones or activators could significantly impact the disease course.
Topics & Concepts
GlucocerebrosidaseParkinson's diseaseDiseaseParkinsonismMedicineAlpha-synucleinNeuroscienceBioinformaticsBiologyInternal medicineLysosomal Storage Disorders ResearchCellular transport and secretionCarbohydrate Chemistry and Synthesis