BMI1 activates P-glycoprotein via transcription repression of miR-3682-3p and enhances chemoresistance of bladder cancer cell
Mingkun Chen, Jun-Hao Zhou, Peng Wang, Yunlin Ye, Yang Liu, Jiawei Zhou, Zijian Chen, Jian-Kun Yang, De-Ying Liao, Zhi-Jian Liang, Xiao Xie, Qi-Zhao Zhou, Kang-Yi Xue, Wenbin Guo, Ming Xia, Ji-Ming Bao, Cheng Yang, Haifeng Duan, Hongyi Wang, Zhipeng Huang, Zike Qin, Cundong Liu
Abstract
(ATP binding cassette subfamily B member 1) gene. Moreover, suppression of P-glycoprotein by miR-3682-3p mimics or its inhibitor XR-9576, could significantly reverse chemoresistance of T24/DDP&GEM cells. These results provided a novel insight into a portion of the mechanism underlying BMI1-mediated chemoresistance in bladder cancer.
Topics & Concepts
GemcitabineBladder cancerCancer researchCisplatinBMI1Downregulation and upregulationChemistryCancerBiologyPharmacologyInternal medicineChemotherapyMedicineGeneBiochemistryBladder and Urothelial Cancer TreatmentsEpigenetics and DNA MethylationUrinary and Genital Oncology Studies