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High-sensitivity and high-resolution therapeutic antibody charge variant and impurity characterization by microfluidic native capillary electrophoresis-mass spectrometry

Zhijie Wu, Hongxia Wang, Jikang Wu, Yu Huang, Xueqing Zhao, Jennifer B. Nguyen, Michael Rosconi, Erica Pyles, Haibo Qiu, Ning Li

2022Journal of Pharmaceutical and Biomedical Analysis30 citationsDOI

Topics & Concepts

ChemistryCapillary electrophoresisAntibodyIsoelectric focusingMonoclonal antibodyChromatographyMass spectrometryBiopharmaceuticalBiochemistryEnzymeImmunologyBiologyGeneticsProtein purification and stabilityMonoclonal and Polyclonal Antibodies ResearchViral Infectious Diseases and Gene Expression in Insects
High-sensitivity and high-resolution therapeutic antibody charge variant and impurity characterization by microfluidic native capillary electrophoresis-mass spectrometry | Litcius