Toward personalization of asthma treatment according to trigger factors
Katarzyna Niespodziana, Kristina Borochova, Petra Pazderova, Thomas Schlederer, Natalia G. Astafyeva, Tatiana Baranovskaya, Mohamed‐Ridha Barbouche, Е. К. Beltyukov, Angelika Berger, Elena Borzova, Jean Bousquet, Roxana Silvia Bumbăcea, Snezhana V. Bychkovskaya, Luis Caraballo, Kian Fan Chung, Adnan Čustović, Guillermo Docena, Thomas Eiwegger, Irina Evsegneeva, Alexander Emelyanov, Peter Errhalt, Р. С. Фассахов, R. M. Fayzullina, E S Fedenko, Daria Fomina, Zhongshan Gao, Pedro Giavina‐Bianchi, Maia Gotua, Susanne Greber‐Platzer, Gunilla Hedlin, N I Ilina, Zhanat Ispayeva, Marco Idzko, Sebastian L. Johnston, Ömer Kalaycı, А. В. Караулов, Antonina Karsonova, Musa Khaitov, Elena Kovzel, M. L. Kowalski, D.А. Kudlаy, Michael Levin, С. Г. Макарова, Paolo Maria Matricardi, Kari C. Nadeau, Leyla S. Namazova-Baranova, O. O. Naumova, Oleksandr Nazarenko, Paul M. O’Byrne, Faith Osier, А Н Пампура, Carmen Panaitescu, Nikolaos G. Papadopoulos, Hae‐Sim Park, Ruby Pawankar, Wolfgang Pohl, Harald Renz, Ksenja Riabova, Vanitha Sampath, Bülent Enis Şekerel, Elopy Sibanda, Valérie Siroux, L. P. Sizyakinа, Jin-Lyu Sun, Zsolt Szépfalusi, Т.Р. Уманец, Hugo P.S. Van Bever, Marianne van Hage, Margarita Vasileva, Erika von Mutius, Jiu‐Yao Wang, Gary Wong, С. В. Зайков, Mihaela Zidarn, Rudolf Valenta
Abstract
Asthma is a severe and chronic disabling disease affecting more than 300 million people worldwide. Although in the past few drugs for the treatment of asthma were available, new treatment options are currently emerging, which appear to be highly effective in certain subgroups of patients. Accordingly, there is a need for biomarkers that allow selection of patients for refined and personalized treatment strategies. Recently, serological chip tests based on microarrayed allergen molecules and peptides derived from the most common rhinovirus strains have been developed, which may discriminate 2 of the most common forms of asthma, that is, allergen- and virus-triggered asthma. In this perspective, we argue that classification of patients with asthma according to these common trigger factors may open new possibilities for personalized management of asthma.