Polymer Encapsulation of Bacterial Biosensors Enables Coculture with Mammalian Cells
Ignacio Moya‐Ramírez, Pavlos Kotidis, Masue Marbiah, Juhyun Kim, Cleo Kontoravdi, Karen M. Polizzi
Abstract
encapsulated within LAMPS. LAMPS enable the formation of a synthetic bacterial-mammalian cell interaction that enables a living biosensor to be integrated into a biomanufacturing process. Our work serves as a proof-of-concept for further applications in bioprocessing since LAMPS combine the simplicity and flexibility of a bacterial biosensor with a viable method to prevent runaway growth that would disturb mammalian cell physiology.
Topics & Concepts
BiomanufacturingBioprocessSynthetic biologyBiosensorCell encapsulationNanotechnologyEscherichia coliCell biologyChemistryBiochemical engineeringBiologyComputational biologyCellBiotechnologyBiochemistryMaterials scienceGeneEngineeringPaleontology3D Printing in Biomedical ResearchGene Regulatory Network Analysisbioluminescence and chemiluminescence research