Synthesis of medium-sized heterocycles from oxetanes based on an allylic amination/ring-opening strategy
Jixing Li, Ming Fang, Maoyan Liao, Hongling Xie, Xiu‐Qin Dong, Zhengyu Han, Jianwei Sun, Hai Huang
Abstract
-aryl oxetan-3-amines undergo allylic amination with zwitterionic π-allylpalladium, followed by intramolecular ring-opening, resulting in the formation of medium-sized heterocycles. Notably, we are able to achieve the synthesis of 7-8 membered heterocycles with moderate to good yields by employing different types of zwitterionic π-allylpalladium species.
Topics & Concepts
AminationAllylic rearrangementRing (chemistry)ChemistryCombinatorial chemistryOrganic chemistryCatalysisSynthesis and Catalytic ReactionsChemical Synthesis and AnalysisCatalytic C–H Functionalization Methods