HIV-1 DNA and Immune Activation Levels Differ for Long-Lived T-Cells in Lymph Nodes, Compared with Peripheral Blood, during Antiretroviral Therapy
Christina Mallarino-Haeger, María Pino, Elise G. Viox, Amélie Pagliuzza, Colin T. King, Kevin Nguyen, Justin Harper, Sol Aldrete, Barbara Cervasi, Keith A. Delman, Michael Lowe, Nicolas Chomont, Vincent C. Marconi, Mirko Paiardini
Abstract
This study provides new insights into the contributions of different CD4 + and CD8 + T-cell subsets to the anatomic differences between LN and blood in individuals with HIV who have optimal versus suboptimal CD4 + T-cell recovery. To our knowledge, this is the first study comparing paired LN and blood CD4 + and CD8 + T-cell differentiation subsets, as well as those subsets in immunological responders versus immunological suboptimal responders.
Topics & Concepts
TIGITBiologyCD8Memory T cellImmunologyCD38Immune systemCytotoxic T cellT cellLymphCell biologyMedicinePathologyIn vitroStem cellGeneticsCD34HIV Research and TreatmentImmune Cell Function and InteractionCytomegalovirus and herpesvirus research