An indole-amide-based phosphine ligand enabling a general palladium-catalyzed sterically hindered Suzuki–Miyaura cross-coupling reaction
Shan Shan Ng, Zicong Chen, On Ying Yuen, Chau Ming So
Abstract
A novel family of indole-amide-based phosphine ligands was designed and synthesized.
Topics & Concepts
ChemistryPhosphineSteric effectsPalladiumAmideCatalysisLigand (biochemistry)AdductIndole testOxidative additionArylDenticityCoupling reactionMedicinal chemistryCombinatorial chemistryOrganic chemistryPolymer chemistryCrystal structureBiochemistryReceptorAlkylCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsAxial and Atropisomeric Chirality Synthesis