Targeting the Hippo/<scp>YAP</scp>/<scp>TAZ</scp> signalling pathway: Novel opportunities for therapeutic interventions into skin cancers
Alexander Howard, Jodie Bojko, Benjamin P. Flynn, Sophie Bowen, Ute Jungwirth, Gernot Walko
Abstract
Skin cancers are by far the most frequently diagnosed human cancers. The closely related transcriptional co-regulator proteins YAP and TAZ (WWTR1) have emerged as important drivers of tumour initiation, progression and metastasis in melanoma and non-melanoma skin cancers. YAP/TAZ serve as an essential signalling hub by integrating signals from multiple upstream pathways. In this review, we summarize the roles of YAP/TAZ in skin physiology and tumorigenesis and discuss recent efforts of therapeutic interventions that target YAP/TAZ in in both preclinical and clinical settings, as well as their prospects for use as skin cancer treatments.
Topics & Concepts
Hippo signaling pathwayRegulatorCancer researchHedgehog signaling pathwaySkin cancerMedicineCarcinogenesisSignallingMetastasisMelanomaCancerSignal transductionBioinformaticsBiologyInternal medicineCell biologyGeneBiochemistryHippo pathway signaling and YAP/TAZWnt/β-catenin signaling in development and cancerPlant Surface Properties and Treatments