Involvement of capsaicin-sensitive nerves in the initiation of swallowing evoked by carbonated water in anesthetized rats
Kojun Tsuji, Takanori Tsujimura, Shogo Sakai, Taku Suzuki, Midori Yoshihara, Kouta Nagoya, Jin Magara, Yoshihide Satoh, Makoto Inoue
Abstract
The initiation of swallowing evoked by laryngeal capsaicin and carbonated water application was diminished by the coapplication of QX-314 and capsaicin. Carbonated water-evoked swallows were also abolished by transection of the superior laryngeal nerves and were inhibited by the acid-sensing ion channel-3 inhibitor. Capsaicin-sensitive nerves are involved in the initiation of carbonated water-evoked swallows.
Topics & Concepts
CapsaicinSwallowingAnesthesiaMedicineInternal medicineSurgeryReceptorNeuroscience of respiration and sleepNeuropeptides and Animal PhysiologyInfant Health and Development