Fascin inhibitor increases intratumoral dendritic cell activation and anti-cancer immunity
Yufeng Wang, Mei Song, Ming Liu, Guoan Zhang, Xian Zhang, Ming O. Li, Xiaojing Ma, J. Jillian Zhang, Xin‐Yun Huang
Abstract
T cells in the otherwise anti-PD-1 refractory tumors. Reduction of fascin levels in cDCs, but not fascin gene knockout in tumor cells, mimics the anti-tumor immune effect of NP-G2-044. These data demonstrate that fascin inhibitor NP-G2-044 simultaneously limits tumor metastasis and reinvigorates anti-tumor immune responses.
Topics & Concepts
FascinInvadopodiaFilopodiaCancer researchMetastasisImmune systemChemistryCD8Cell biologyCancer cellBiologyImmunologyCancerActinGeneticsImmunotherapy and Immune ResponsesCellular Mechanics and InteractionsT-cell and B-cell Immunology