Long-Term Outcomes of Congenital Adrenal Hyperplasia
Anna Nordenström, Svetlana Lajić, Henrik Falhammar
Abstract
A plethora of negative long-term outcomes have been associated with congenital adrenal hyperplasia (CAH). The causes are multiple and involve supra-physiological gluco- and mineralocorticoid replacement, excess adrenal androgens both intrauterine and postnatal, elevated steroid precursor and adrenocorticotropic hormone levels, living with a congenital condition as well as the proximity of the cytochrome P450 family 21 subfamily A member 2 (CYP21A2) gene to other genes. This review aims to discuss the different long-term outcomes of CAH.
Topics & Concepts
Congenital adrenal hyperplasiaMedicineEndocrinologyInternal medicineAdrenocorticotropic hormoneSubfamilyMineralocorticoidHormoneAldosteroneGeneBiologyGeneticsSexual Differentiation and DisordersGrowth Hormone and Insulin-like Growth FactorsHormonal and reproductive studies