Novel quinazoline-based dual EGFR/c-Met inhibitors overcoming drug resistance for the treatment of NSCLC: Design, synthesis and anti-tumor activity
Han Zhang, Wenhui Gan, Dang Fan, Pengwu Zheng, Qiao‐Li Lv, Qingshan Pan, Wufu Zhu
Topics & Concepts
T790MAfatinibIn vivoEGFR inhibitorsPharmacologyCancer researchChemistryKinaseIn vitroGefitinibEpidermal growth factor receptorTyrosine kinaseQuinazolineCell growthCell cycle checkpointCancerApoptosisCell cycleMedicineSignal transductionBiologyReceptorBiochemistryInternal medicineCombinatorial chemistryBiotechnologyQuinazolinone synthesis and applicationsLung Cancer Treatments and MutationsCancer therapeutics and mechanisms