The therapeutic efficacy and clinical translation of mesenchymal stem cell-derived exosomes in cardiovascular diseases
Huan Zhang, Xueqi Wan, Jinfan Tian, Ziyu An, Libo Liu, Xin Zhao, Yuquan Zhou, Lijun Zhang, Chang-Jiang Ge, Xiantao Song
Abstract
Exosomes, mainly derived from mesenchymal stem cells, provide a good reference for cardiac function repair and clinical application in cardiac and vascular diseases by regulating cardiomyocyte viability, inflammatory levels, angiogenesis, and ventricular remodeling after a heart injury. This review presents the cardioprotective efficacy of mesenchymal stem cell-originated exosomes and explores the underlying molecular mechanisms. Furthermore, we expound on several efficient approaches to transporting exosomes into the heart in clinical application and comment on the advantages and disadvantages of each method.
Topics & Concepts
Mesenchymal stem cellMicrovesiclesAngiogenesisMedicineExosomeStem cellCardiac function curveCancer researchTranslation (biology)Cardiac cellHeart failureCell biologyBioinformaticsPathologyBiologymicroRNACardiologyInternal medicineMessenger RNAGeneBiochemistryExtracellular vesicles in diseaseCardiovascular Effects of ExerciseElectrospun Nanofibers in Biomedical Applications