Synthesis and biological evaluation of novel 18F-labeled phenylbenzofuran-2-carboxamide derivative for detection of orexin 1 receptor in the brain
Hiroyuki Watanabe, Yuki Idoko, Shimpei Iikuni, Takuji Ide, Yoichi Shimizu, Yuji Nakamoto, Masahiro Ono
Topics & Concepts
In vivoChemistryOrexinReceptorBiodistributionCarboxamideOrexin receptorPharmacologyPositron emission tomographyLigand (biochemistry)NeuroscienceBiophysicsInternal medicineBiochemistryIn vitroBiologyNeuropeptideMedicineBiotechnologySleep and Wakefulness ResearchPhotochromic and Fluorescence ChemistryCircadian rhythm and melatonin