The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition
M. Sacco, Yanmei Hu, Maura V. Gongora, Flora Meilleur, M. Trent Kemp, Xiujun Zhang, Jun Wang, Yu Chen
Topics & Concepts
BiologyProteaseMutationDrugVirologySmall moleculeGeneticsBiochemistryEnzymePharmacologyGeneSARS-CoV-2 and COVID-19 ResearchComputational Drug Discovery Methodsthermodynamics and calorimetric analyses