Indolyl-based Copper(I) Complex-Catalyzed Intermolecular Trifluoromethylazolation of Alkenes via Radical Process
Qingbing Yuan, Zeming Huang, Zhuo Chai, Dongjing Hong, Shan Zhu, Shuangliu Zhou, Xiancui Zhu, Yun Wei, Shaowu Wang
Abstract
Herein, we synthesized and characterized a binuclear copper(I) complex supported by the indolyl-based ligand. Employing this complex as catalyst, we have developed a three-component intermolecular trifluoromethylazolation of alkenes to deliver various trifluoromethylated azole derivatives. The method features exclusive chemo- and regioselectivity, a broad scope of alkenes and oxazoles, thiazoles, and good tolerance of functional groups under mild conditions. Preliminary mechanistic studies support a radical process for the transformation.
Topics & Concepts
ChemistryIntermolecular forceRegioselectivityAzoleCatalysisLigand (biochemistry)RadicalCombinatorial chemistryCopperOrganic chemistryMoleculeAntifungalReceptorDermatologyMedicineBiochemistryFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsRadical Photochemical Reactions