Dynamic supramolecular self-assembly of platinum(<scp>ii</scp>) complexes perturbs an autophagy–lysosomal system and triggers cancer cell death
Ka‐Chung Tong, Pui‐Ki Wan, Chun‐Nam Lok, Chi‐Ming Che
Abstract
energy-dependent endocytosis, and eventually transform into other superstructures distributed in endosomal/lysosomal and mitochondrial compartments apparently following cleavage of the glycosidic linkage. Accompanying the formation of platinum-containing superstructures are increased autophagic vacuole formation, lysosomal membrane permeabilization, and mitochondrial membrane depolarization, as well as anti-tumor activity of 1a in a mouse xenograft model. These findings highlight the dynamic, multi-stage extracellular and intracellular supramolecular self-assembly of planar platinum(ii) complexes driven by modular intermolecular interactions with potential anti-cancer application.
Topics & Concepts
AutophagyPlatinumSupramolecular chemistryProgrammed cell deathCancer cellChemistryCell biologyCancerCellSelf-assemblyNanotechnologyBiochemistryMaterials scienceBiologyMoleculeApoptosisCatalysisOrganic chemistryGeneticsMetal complexes synthesis and propertiesAdvanced Nanomaterials in CatalysisPorphyrin and Phthalocyanine Chemistry