Nicotine affects mitochondrial structure and function in human airway smooth muscle cells
Niyati A. Borkar, Michael A. Thompson, Colleen M. Bartman, Venkatachalem Sathish, Y. S. Prakash, Christina M. Pabelick
2023American Journal of Physiology-Lung Cellular and Molecular Physiology25 citationsDOIOpen Access PDF
Abstract
Asthma is a major healthcare burden, which is further exacerbated by smoking. Recognizing the smoking risk of asthma, understanding the effects of nicotine on asthmatic airways becomes critical. Surprisingly, the mechanisms of nicotine action, even in normal and especially asthmatic airways, are understudied. Accordingly, the goal of this research is to investigate how nicotine influences asthmatic airways in terms of mitochondrial structure and function, via the a7nAChR.
Topics & Concepts
AsthmaNicotineMedicineAirwaySmooth muscleSmoking cessationImmunologyInternal medicineAnesthesiaPathologyNicotinic Acetylcholine Receptors StudyReceptor Mechanisms and SignalingCircadian rhythm and melatonin