Structural and Clinical Correlates of a Periventricular Gradient of Neuroinflammation in Multiple Sclerosis
Émilie Poirion, Mattéo Tonietto, François‐Xavier Lejeune, Vito A. G. Ricigliano, Marine Boudot de la Motte, Charline Benoit, G. Béra, Bertrand Kühnast, Michel Bottlaender, Benedetta Bodini, Bruno Stankoff
Abstract
OBJECTIVES: F]-DPA714 PET and to investigate its relationship with periventricular microstructural damage, evaluated by magnetization transfer ratio (MTR), and with trajectories of disability worsening. METHODS: F]-DPA714 TSPO dynamic PET, from which individual maps of voxels characterized by innate immune cell activation (DPA+) were generated. White matter (WM) was divided in 3-mm-thick concentric rings radiating from the ventricular surface toward the cortex, and the percentage of DPA+ voxels and mean MTR were extracted from each ring. Two-year trajectories of disability worsening were collected to identify patients with and without recent disability worsening. RESULTS: = 0.025). CONCLUSIONS: Our results demonstrate that in MS the innate immune cell activation predominates in periventricular regions and is associated with microstructural damage and disability worsening. This could result from the diffusion of proinflammatory CSF-derived factors into surrounding tissues.