Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding
Gottfried J. Palm, Ina Buchholz, Sebastiaan Werten, Britta Girbardt, Leona Berndt, Mihaela Delcea, Winfried Hinrichs
Topics & Concepts
TetRIsothermal titration calorimetryAllosteric regulationChemistryCooperativityCooperative bindingTetracyclineRepressorCrystallographyBinding siteInducerCircular dichroismLac repressorStereochemistryBiophysicsBiochemistryBiologyGene expressionEnzymeGeneAntibioticsDNA and Nucleic Acid ChemistryCancer therapeutics and mechanismsDrug Transport and Resistance Mechanisms