Roseoflavin, a Natural Riboflavin Analogue, Possesses <i>In Vitro</i> and <i>In Vivo</i> Antiplasmodial Activity
Ayman Hemasa, Matthias Mack, Kevin J. Saliba
Abstract
in mice. We found that roseoflavin decreased the parasitemia by 46-fold following a 4 day suppression test and, on average, increased the survival of mice by 4 to 5 days. Our data are consistent with riboflavin metabolism and/or the utilization of riboflavin-derived cofactors being viable drug targets for the development of new antimalarials and that roseoflavin could serve as a potential starting point.
Topics & Concepts
RiboflavinFlavin groupFlavin adenine dinucleotideIn vivoBiochemistryParasitemiaBiologyPlasmodium falciparumIn vitroFlavin mononucleotideCofactorDihydrofolate reductaseMalariaPharmacologyEnzymeImmunologyBiotechnologyPhotosynthetic Processes and MechanismsAmino Acid Enzymes and MetabolismCassava research and cyanide