Uric acid induces stress resistance and extends the life span through activating the stress response factor DAF-16/FOXO and SKN-1/NRF2
Qin-Li Wan, Xiaodie Fu, Wenyu Dai, Jing Yang, Zhenhuan Luo, Xiao Meng, Xiao Liu, Ruowei Zhong, Hengwen Yang, Qinghua Zhou
Abstract
, in part, because of its antioxidative activity, which in turn regulates the IIS and the reproductive signaling pathways, thereby activating the function of the transcription factors DAF-16, HSF-1 and SKN-1.
Topics & Concepts
Uric acidBiologyTranscription factorCell biologyOxidative stressSignal transductionDownregulation and upregulationCaenorhabditis elegansBiochemistryLongevityGeneGeneticsGenetics, Aging, and Longevity in Model OrganismsSelenium in Biological SystemsGenomics, phytochemicals, and oxidative stress