An Antibiotic-Impacted Microbiota Compromises the Development of Colonic Regulatory T Cells and Predisposes to Dysregulated Immune Responses
Xiaozhou Zhang, Timothy C. Borbet, Angela Fallegger, Matthew F. Wipperman, Martin J. Blaser, Anne Müller
Abstract
T cells, particularly of colonic regulatory T cells. This Treg deficiency cannot be corrected by cohousing with normal mice later and is recapitulated by reconstitution of germfree mice with microbiota harvested from antibiotic-exposed donors. As a consequence of their dysbiosis, and possibly of their Treg deficiency, antibiotic-impacted offspring generate dysregulated Th1 responses to bacterial challenge infection and develop more severe symptoms of ovalbumin-induced anaphylaxis.
Topics & Concepts
AntibioticsImmune systemImmunologyMucosal immunologyMicrobiomeMedicineBiologyMicrobiologyImmunityBioinformaticsGut microbiota and healthClostridium difficile and Clostridium perfringens researchInfant Nutrition and Health