Inferring the Allelic Series at QTL in Multiparental Populations
Wesley L. Crouse, Samir N. P. Kelada, William Valdar
Abstract
Synthetic Population Resource (DSPR). We find that, although posterior inference of the exact allelic series is often uncertain, we are able to distinguish biallelic QTL from more complex multiallelic cases. Additionally, our allele-based approach improves haplotype effect estimation when the true number of functional alleles is small. Our method, Tree-Based Inference of Multiallelism via Bayesian Regression (TIMBR), provides new insight into the genetic architecture of QTL in MPPs.
Topics & Concepts
BiologyGeneticsAlleleQuantitative trait locusSeries (stratigraphy)Evolutionary biologyGenePaleontologyGenetic Mapping and Diversity in Plants and AnimalsGene expression and cancer classificationGenetic and phenotypic traits in livestock