Pretransplant MRD detection of fusion transcripts is strongly prognostic in <i>KMT2A-</i>rearranged acute myeloid leukemia
Sun Loo, Nicola Potter, Adam Ivey, Jenny O’Nions, Roderick Moon, Jelena Jovanović, Chun Yew Fong, Natasha S. Anstee, Ing Soo Tiong, Jad Othman, Chong Chyn Chua, H W Renshaw, Robert Baker, Shaun Fleming, Nigel H. Russell, David Ritchie, Ashish Bajel, Hsin‐An Hou, Richard Dillon, Andrew H. Wei
Abstract
ABSTRACT: Pretransplant detection of KMT2Ar measurable residual disease ≥0.001% by quantitative polymerase chain reaction was associated with significantly inferior posttransplant survival (2-year relapse-free survival 17% vs 59%; P = .001) and increased 2-year cumulative incidence of relapse (75% vs 25%, P = .0004).
Topics & Concepts
Cumulative incidenceMedicineInternal medicineMyeloid leukemiaIncidence (geometry)OncologyFusion geneLeukemiaGastroenterologyTransplantationBiologyGeneGeneticsPhysicsOpticsAcute Myeloid Leukemia ResearchChronic Myeloid Leukemia TreatmentsProtein Degradation and Inhibitors