Partitioning heritability by functional annotation using genome-wide association summary statistics
Hilary K. Finucane, Brendan Bulik‐Sullivan, Alexander Gusev, Gosia Trynka, Yakir Reshef, Po‐Ru Loh, Verneri Anttila, Han Xu, Chongzhi Zang, Kyle Kai-How Farh, Stephan Ripke, Felix R. Day, Shaun Purcell, Eli A. Stahl, Sara Lindström, John R. B. Perry, Yukinori Okada, Soumya Raychaudhuri, Mark J. Daly, Nick Patterson, Benjamin M. Neale, Alkes L. Price
Topics & Concepts
BiologyHeritabilityGenome-wide association studyGenetic associationMissing heritability problemComputational biologyAnnotationAssociation (psychology)GenomeGeneticsEvolutionary biologyStatisticsSingle-nucleotide polymorphismGeneGenotypeMathematicsPhilosophyEpistemologyGenetic Associations and EpidemiologyGenomics and Chromatin DynamicsCancer-related molecular mechanisms research