Nanoscale Drug Delivery Systems in Glioblastoma
Zihao Liu, Xiaoshuai Ji, He Dong, Rui Zhang, Qian Liu, Tao Xin
Abstract
Glioblastoma is the most aggressive cerebral tumor in adults. However, the current pharmaceuticals in GBM treatment are mainly restricted to few chemotherapeutic drugs and have limited efficacy. Therefore, various nanoscale biomaterials that possess distinct structure and unique property were constructed as vehicles to precisely deliver molecules with potential therapeutic effect. In this review, nanoparticle drug delivery systems including CNTs, GBNs, C-dots, MOFs, Liposomes, MSNs, GNPs, PMs, Dendrimers and Nanogel were exemplified. The advantages and disadvantages of these nanoparticles in GBM treatment were illustrated.
Topics & Concepts
NanochemistryDrug deliveryNanotechnologyGlioblastomaNanoscopic scaleMaterials scienceDrugMedicinePharmacologyCancer researchNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsGraphene and Nanomaterials Applications