Comparison of Contrast‐Enhanced Spectral Mammography and Contrast‐Enhanced MRI in Screening Multifocal and Multicentric Lesions in Breast Cancer Patients
Lei Feng, Sheng Lei, Litao Zhang, Na Li, Yuanzhong Xie
Abstract
Objectives . We aimed to determine the difference between contrast‐enhanced spectral mammography (CESM) and contrast‐enhanced magnetic resonance imaging (CE‐MRI) in detecting multifocal and multicentric breast cancer (MMBC). Methods : This study was conducted among breast cancer patients between July 1, 2017, and May 30, 2021. The sensitivity, specificity, and accuracy of CESM and CE‐MRI in the diagnosis of MMBC were evaluated with pathological results as the gold standard. Results . A total of 188 lesions were detected in 54 patients with MMBC, including 177 breast cancer and 11 benign lesions. Based on CESM and CE‐MRI, 4 false‐positive cases and 3 false‐negative cases and 7 false‐positive cases and 1 false‐negative case, respectively, were found. The accuracy of CESM was higher than that of MRI (96.3% vs 95.7%), and the specificity was higher than that of MRI (63.6% vs 36.4%). There were no significant differences in the sensitivity, specificity, and accuracy for the detection of MMBC between CESM and CE‐MRI ( p = 0.500; p = 0.250; p = 0.792). Conclusion . CESM is an effective method for the detection of MMBC, which is consistent with the sensitivity and accuracy of CE‐MRI.