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CAR-redirected natural killer T cells demonstrate superior antitumor activity to CAR-T cells through multimodal CD1d-dependent mechanisms

Xin Zhou, Ying Wang, Zhangqi Dou, Gloria Delfanti, Ourania Tsahouridis, Caroline Marnata Pellegry, Manuela Zingarelli, Gatphan Atassi, Mark G. Woodcock, Giulia Casorati, Paolo Dellabona, William Y. Kim, Linjie Guo, Barbara Savoldo, Ageliki Tsagaratou, J. Justin Milner, Leonid S. Metelitsa, Gianpietro Dotti

2024Nature Cancer46 citationsDOIOpen Access PDF

Topics & Concepts

CD1DNatural killer T cellImmunologyBiologyImmune systemT cellCAR-T cell therapy researchImmune Cell Function and InteractionT-cell and B-cell Immunology
CAR-redirected natural killer T cells demonstrate superior antitumor activity to CAR-T cells through multimodal CD1d-dependent mechanisms | Litcius